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    Internal Exposure of Children by Simulated Acute Inhalation of Volatile Organic Compounds: The Influence of Chemical Properties on the Child/Adult Concentration Ratio


    Abraham, K. and Mielke, H. and Huisinga, W. and Gundert-Remy, U. (2005) Internal Exposure of Children by Simulated Acute Inhalation of Volatile Organic Compounds: The Influence of Chemical Properties on the Child/Adult Concentration Ratio. Basic & Clinical Pharmacology & Toxicology (BCPT), 96 (3). pp. 242-243. ISSN 1742-7843

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    Official URL: http://www3.interscience.wiley.com/cgi-bin/fulltex...


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    Abstract

    A specific exposure scenario, namely the accidental release of industrial chemicals leading to an airborne exposure over a wide range of concentrations, requires special consideration in the risk assessment including that of sensitive subpopulations. In this context, children may be at higher risk compared to adults due to possible higher external exposure (behaviour, physiology), different kinetics (both leading to higher internal exposure) and different dynamics. The scope of this paper is the quantification of the age-dependent differences in the kinetics of children occurring during inhalation of volatile organic compounds (VOCs).

    Item Type: Article
    Additional Information: The definitive version is available at http://www3.interscience.wiley.com/cgi-bin/fulltext/118719013/PDFSTART
    Keywords: Children; Inhalation; Kinetics; Model; Risk assessment; Hamilton Institute.
    Academic Unit: Faculty of Science and Engineering > Biology
    Faculty of Science and Engineering > Chemistry
    Faculty of Science and Engineering > Research Institutes > Hamilton Institute
    Item ID: 1846
    Identification Number: https://doi.org/10.1111/j.1742-7843.2005.pto960315.x
    Depositing User: Hamilton Editor
    Date Deposited: 15 Feb 2010 17:10
    Journal or Publication Title: Basic & Clinical Pharmacology & Toxicology (BCPT)
    Publisher: Wiley-Blackwell Publishing Ltd.
    Refereed: No
    URI:

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