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    Metal free, “click and click–click” conjugation of ribonucleosides and 2′-OMe oligoribonucleotides on the solid phase


    Singh, Ishwar and Heaney, Frances (2010) Metal free, “click and click–click” conjugation of ribonucleosides and 2′-OMe oligoribonucleotides on the solid phase. Organic & Biomolecular Chemistry, 8 (3). pp. 451-456. ISSN 1477-0520

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    Abstract

    A fast and practical metal free conjugation of ribonucleosides and 2¢-OMe 4-mer oligoribonucleotides has been accomplished by a nitrile oxide alkyne click cycloaddition reaction on the solid-phase, the methodology is suited to modification at either, or both, the 3¢- or the 5¢-terminus of the oligoribonucleotide substrate.

    Item Type: Article
    Keywords: Metal free; “click and click–click” conjugation; ribonucleosides; 2′-OMe oligoribonucleotides;
    Academic Unit: Faculty of Science and Engineering > Chemistry
    Item ID: 4293
    Depositing User: Dr. Frances Heaney
    Date Deposited: 09 Apr 2013 10:37
    Journal or Publication Title: Organic & Biomolecular Chemistry
    Publisher: Royal Society of Chemistry
    Refereed: Yes
    URI:

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