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    Chaperoning prions: the story unfolds


    O'Connor, David and Jones, Gary (2006) Chaperoning prions: the story unfolds. Biotech International (18). pp. 6-10.

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    Abstract

    Prions are infectious proteins that are responsible for a number of mammalian degenerative diseases. The discovery of prions in yeast has allowed detailed genetic analysis to be carried out to identify cellular factors involved in prion propagation. It is now clear that a complex relationship exists between molecular chaperones and prion propagation. Prions may actually have evolved to exploit the cell's chaperone machinery to ensure their own propagation.

    Item Type: Article
    Keywords: prions; prion propagation; chaperones; yeast;
    Academic Unit: Faculty of Science and Engineering > Research Institutes > Hamilton Institute
    Item ID: 6020
    Identification Number: http://www.biotech-online.com
    Depositing User: Dr. Gary Jones
    Date Deposited: 10 Apr 2015 16:12
    Journal or Publication Title: Biotech International
    Publisher: PanGlobal Media
    Refereed: No
    URI:

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