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    The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling


    Moynagh, Paul N. (2009) The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling. Trends in Immunology, 30 (1). pp. 33-42. ISSN 1471-4906

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    Abstract

    This review highlights the emerging roles of the Pellino family of E3 ubiquitin ligases as upstream mediators in Toll-like receptor (TLR) pathways that lead to activation of MAP kinases and transcription factors. The functional importance of the Pellino family as RING-like-domain-containing proteins with intrinsic ubiquitin E3 ligase activity that can catalyse polyubiquitylation of the key TLR signalling molecule IRAK1 is discussed in detail. The importance of Pellino proteins as novel targets for mediating negative regulation of TLR signalling is also explored. This new knowledge and understanding of Pellino biology begins to fill some long-standing voids in our understanding of TLR signalling.

    Item Type: Article
    Additional Information: The definitive published version of this article is available at DOI: 10.1016/j.it.2008.10.001
    Keywords: Pellino family; IRAK E3 ligases; innate immune signalling; toll-like receptor pathways;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 7199
    Identification Number: https://doi.org/10.1016/j.it.2008.10.001
    Depositing User: Professor Paul Moynagh
    Date Deposited: 18 Jul 2016 15:57
    Journal or Publication Title: Trends in Immunology
    Publisher: Elsevier
    Refereed: Yes
    Funders: Science Foundation Ireland (SFI)
    URI:

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