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    Proteomic profiling of animal models mimicking skeletal muscle disorders


    Doran, Philip and Gannon, Joan and O'Connell, Kathleen and Ohlendieck, Kay (2007) Proteomic profiling of animal models mimicking skeletal muscle disorders. Proteomics Clinical Applications, 1 (9). pp. 1169-1184. ISSN 1862-8346

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    Abstract

    Over the last few decades of biomedical research, animal models of neuromuscular diseases have been widely used for determining pathological mechanisms and for testing new therapeutic strategies. With the emergence of high-throughput proteomics technology, the identification of novel protein factors involved in disease processes has been decisively improved. This review outlines the usefulness of the proteomic profiling of animal disease models for the discovery of new reliable biomarkers, for the optimization of diagnostic procedures and the development of new treatment options for skeletal muscle disorders. Since inbred animal strains show genetically much less interindividual differences as compared to human patients, considerably lower experimental repeats are capable of producing meaningful proteomic data. Thus, animal model proteomics can be conveniently employed for both studying basic mechanisms of molecular pathogenesis and the effects of drugs, genetic modifications or cell-based therapies on disease progression. Based on the results from comparative animal proteomics, a more informed decision on the design of clinical proteomics studies could be reached. Since no one animal model represents a perfect pathobiochemical replica of all of the symptoms seen in complex human disorders, the proteomic screening of novel animal models can also be employed for swift and enhanced protein biochemical phenotyping.

    Item Type: Article
    Keywords: Animal disease model; Animal proteomics; Biomarker; DIGE; Disease marker;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 7505
    Identification Number: https://doi.org/10.1002/prca.200700042
    Depositing User: Prof. Kay Ohlendieck
    Date Deposited: 11 Oct 2016 15:25
    Journal or Publication Title: Proteomics Clinical Applications
    Publisher: Wiley
    Refereed: Yes
    Funders: Science Foundation Ireland (SFI), Health Research Board (HRB), Muscular Dystrophy Ireland
    URI:

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