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    A Study of Sequence Distribution of a Painted Globule as a Model for Proteins with Good Folding Properties


    Kechadi, M.-T. and Reilly, Ronan and Dawson, K.A. and Kuznetsov, Y. and Timoshenko, E.G. (1998) A Study of Sequence Distribution of a Painted Globule as a Model for Proteins with Good Folding Properties. Il Nuovo Cimento D, 20 (12). pp. 2383-2391. ISSN 0392-6737

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    Abstract

    In this paper we present a method to study the folding structure of a simple model consisting of two kinds of monomers, hydrophobic and hydrophilic. This method has three main steps: an efficient simulation method to bring an open sequence of homopolymer to a folded state, the application of a painting method called regular hull to the folded globule and the refolding process of the obtained copolymer sequence. This study allows us to suggest a theoretical function of disorder distribution for copolymer sequences that give rise to a compacted and well micro-phase separated globule.

    Item Type: Article
    Additional Information: Preprint version of article which was published on arXiv at arXiv:cond-mat/0104440
    Keywords: A Study of Sequence Distribution of a Painted Globule as a Model for Proteins with Good Folding Properties
    Academic Unit: Faculty of Science and Engineering > Computer Science
    Item ID: 8205
    Depositing User: Prof. Ronan Reilly
    Date Deposited: 11 May 2017 15:40
    Journal or Publication Title: Il Nuovo Cimento D
    Publisher: Società Italiana di Fisica
    Refereed: Yes
    URI:

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