Duffy, Ken R. and Hodgkin, Philip D. (2012) Intracellular competition for fates in the immune system. Trends in Cell Biology, 22 (9). pp. 457-464. ISSN 0962-8924

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Abstract

During an adaptive immune response, lymphocytes proliferate for five to 20 generations, differentiating to take on effector functions, before cessation and cell death become dominant. Recent experimental methodologies enable direct observation of individual lymphocytes and the times at which they adopt fates. Data from these experiments reveal diversity in fate selection, heterogeneity and involved correlation structures in times to fate, as well as considerable familial correlations. Despite the significant complexity, these data are consistent with the simple hypothesis that each cell possesses autonomous processes, subject to temporal competition, leading to each fate. This article addresses the evidence for this hypothesis, its hallmarks, and, should it be an appropriate description of a cell system, its ramifications for manipulation.

Item Type:	Article
Keywords:	adaptive immune response; stochastic fate determination; autonomous competition hypothesis;
Academic Unit:	Faculty of Science and Engineering > Research Institutes > Hamilton Institute
Item ID:	10170
Identification Number:	https://doi.org/10.1016/j.tcb.2012.05.004
Depositing User:	Dr Ken Duffy
Date Deposited:	02 Nov 2018 16:40
Journal or Publication Title:	Trends in Cell Biology
Publisher:	Elsevier
Refereed:	Yes
URI:	https://www.sciencedirect.com
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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