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    Differential expression of immediate early genes Zif268 and c-Fos in the hippocampus and prefrontal cortex following spatial learning and glutamate receptor antagonism


    Commins, Sean and Farina, Francesca (2016) Differential expression of immediate early genes Zif268 and c-Fos in the hippocampus and prefrontal cortex following spatial learning and glutamate receptor antagonism. Behavioural Brain Research, 307. pp. 194-198. ISSN 0166-4328

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    Abstract

    The objective of this study was to examine the effects of NMDAR and AMPAR antagonism on the expression of Zif268 and c-Fos in the hippocampus and medial prefrontal cortex during spatial memory encoding in rats trained in the Morris water maze. NMDAR inhibition impaired navigation and significantly attenuated expression of Zif268, but not c-Fos, in area CA1. AMPAR channel blockade had little effect on learning or IEG expression. Overall, Zif268 and c-Fos displayed markedly different patterns of hippocampal and prefrontal expression, with Zif268 being more closely linked to spatial learning.

    Item Type: Article
    Keywords: Glutamate receptors; Immediate early genes; Hippocampus; Prefrontal cortex; Spatial memory;
    Academic Unit: Faculty of Science and Engineering > Psychology
    Item ID: 10693
    Identification Number: https://doi.org/10.1016/j.bbr.2016.04.002
    Depositing User: Dr. Sean Commins
    Date Deposited: 05 Apr 2019 16:25
    Journal or Publication Title: Behavioural Brain Research
    Publisher: Elsevier
    Refereed: Yes
    URI:

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