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    Interaction between paired-pulse facilitation and long-term potentiation in the projection from hippocampal area CA1 to the entorhinal cortex


    Craig, Sarah and Commins, Sean (2005) Interaction between paired-pulse facilitation and long-term potentiation in the projection from hippocampal area CA1 to the entorhinal cortex. Neuroscience Research, 53 (2). pp. 140-146. ISSN 0168-0102

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    Abstract

    The hippocampus communicates with the neocortex via the entorhinal cortex and is thought to be critically involved in the consolidation of memories. This paper contains in vivo evidence of a projection from the hippocampal area CA1 to the entorhinal cortex. Current theories of memory formation suggest that the backprojections from the hippocampus to the neocortex should undergo some form of plastic change in order that memories become consolidated. Paired-pulse facilitation (PPF) and long-term potentiation (LTP) are forms of short- and long-term plasticity, respectively. We show that the CA1 to entorhinal cortex projection is capable of sustaining PPF over a wide range of stimulus intervals. In addition we demonstrate that following high frequency stimulation of this pathway the evoked response in the entorhinal cortex remains potentiated for at least 30 min. Finally, we demonstrate that PPF changes following LTP depending on the initial ratio of PPF, suggesting that LTP expression on this pathway may contain a presynaptic component. These findings should provide insight into the hippocampal function in memory formation.

    Item Type: Article
    Keywords: Long-term potentiation (LTP); Paired-pulse facilitation (PPF); Presynaptic; Hippocampus; CA1; Entorhinal cortex; Synaptic plasticity; Memory;
    Academic Unit: Faculty of Science and Engineering > Psychology
    Item ID: 10700
    Identification Number: https://doi.org/10.1016/j.neures.2005.06.009
    Depositing User: Dr. Sean Commins
    Date Deposited: 09 Apr 2019 14:02
    Journal or Publication Title: Neuroscience Research
    Publisher: Elsevier
    Refereed: Yes
    URI:

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