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    Cyclooxygenase inhibition attenuates endotoxin-induced spatial learning deficits, but not an endotoxin-induced blockade of long-term potentiation


    Shawa, Kendra N. and Commins, Sean and O'Mara, Shane (2005) Cyclooxygenase inhibition attenuates endotoxin-induced spatial learning deficits, but not an endotoxin-induced blockade of long-term potentiation. Brain Research, 1038 (2). pp. 231-237. ISSN 0006-8993

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    Abstract

    Peripheral administration of lipopolysaccharide (LPS), a potent bacterial endotoxin, can cause a variety of central effects, including production of cytokines and cyclooxygenases in the brain, as well as peripheral increases in corticosterone. These, in turn, may contribute to neuroimmune-induced neurocognitive deficits. We show here LPS causes deficits in hippocampal-dependent spatial learning in the water maze but that treatment with ibuprofen, a broad-spectrum cyclooxygenase inhibitor, reverses the deficits induced in spatial learning by LPS. We also show that LPS causes an impairment in the induction of long-term potentiation in the dentate gyrus in vivo, a major contemporary model of learning and memory. No differences were found in corticosterone levels in trunk blood but we find a decrease in brain-derived neurotrophic factor (BDNF) expression in LPS group compared to saline controls. Paradoxically compared to the behavioral findings treatment with ibuprofen does not attenuate the LPS-induced impairment in LTP or BDNF concentration in tetanized tissue.

    Item Type: Article
    Keywords: Cyclooxygenase inhibition; Lipopolysaccharide; Long-term potentiation;
    Academic Unit: Faculty of Science and Engineering > Psychology
    Item ID: 10716
    Identification Number: /10.1016/j.brainres.2005.01.035
    Depositing User: Dr. Sean Commins
    Date Deposited: 10 Apr 2019 14:54
    Journal or Publication Title: Brain Research
    Publisher: Elsevier
    Refereed: Yes
    Funders: European Commission (EC), Health Research Board (HRB)
    URI:

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