Wyse, C.A. and Coogan, Andrew and Selman, C. and Hazlerigg, D.G. and Speakman, J.R. (2010) Association between mammalian lifespan and circadian free-running period: the circadian resonance hypothesis revisited. Biology Letters of the Royal Society of London, 6 (5). pp. 696-698. ISSN 1744-9561

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Abstract

Biological rhythms that oscillate with periods close to 24 h (circadian cycles) are pervasive features of mammalian physiology, facilitating entrainment to the 24 h cycle generated by the rotation of the Earth. In the absence of environmental time cues, circadian rhythms default to their endogenous period called tau, or the free-running period. This sustained circadian rhythmicity in constant conditions has been reported across the animal kingdom, a ubiquity that could imply that innate rhythmicity confers an adaptive advantage. In this study, we found that the deviation of tau from 24 h was inversely related to the lifespan in laboratory mouse strains, and in other rodent and primate species. These findings support the hypothesis that misalignment of endogenous rhythms and 24 h environmental cycles may be associated with a physiological cost that has an effect on longevity.

Item Type:	Article
Keywords:	circadian; tau; lifespan; free-running; rodent; primate;
Academic Unit:	Faculty of Science and Engineering > Psychology
Item ID:	10720
Identification Number:	https://doi.org/10.1098/rsbl.2010.0152
Depositing User:	Dr. Andrew Coogan
Date Deposited:	12 Apr 2019 16:19
Journal or Publication Title:	Biology Letters of the Royal Society of London
Publisher:	The Royal Society
Refereed:	Yes
URI:	https://royalsocietypublishing.org
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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