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    Daily methylphenidate and atomoxetine treatment impacts on clock gene protein expression in the mouse brain


    Baird, Alison and Coogan, Andrew and Kaufling, Jennifer and Barrot, Michel and Thome, Johannes (2013) Daily methylphenidate and atomoxetine treatment impacts on clock gene protein expression in the mouse brain. Brain Research, 1513. pp. 61-71. ISSN 0006-8993

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    Abstract

    Circadian rhythms are repeating patterns of physiological and other parameters that recur with periods of approximately 24 h, and are generated by an endogenous circadian timekeeping mechanism. Such circadian rhythms, and their underlying molecular mechanisms, are known to be altered by a number of central nervous system acting pharmacological compounds, as well as becoming perturbed in a number of common psychiatric and neurological conditions. The psychostimulant methylphenidate and the non-stimulant atomoxetine are used in the pharmacotherapy of attention deficit hyperactivity disorder, a common condition in which circadian rhythms have been reported to be altered. In the present study we have examined the effects of daily methylphenidate or atomoxetine treatment across 7 days on circadian clock gene product expression across numerous brain regions in the male mouse to test the potential impact of such compounds on circadian timing. We report drug, brain region and molecular specific effects of such treatments, including alterations in expression profiles in the suprachiasmatic nucleus, the master circadian pacemaker. These results indicate that drugs used in the clinical management of attention deficit hyperactivity disorder can alter molecular factors that are believed to underpin circadian timekeeping, and such effects may be of importance in both the therapeutic and side effect profiles of such drugs.

    Item Type: Article
    Keywords: Circadian; Methylphenidate; Atomoxetine; Suprachiasmatic; ADHD;
    Academic Unit: Faculty of Science and Engineering > Psychology
    Item ID: 10731
    Identification Number: https://doi.org/10.1016/j.brainres.2013.03.038
    Depositing User: Dr. Andrew Coogan
    Date Deposited: 16 Apr 2019 14:36
    Journal or Publication Title: Brain Research
    Publisher: Elsevier
    Refereed: Yes
    URI:

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