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    Synthesis of pyrazolopyrimidinones using a “one-pot” approach under microwave irradiation


    Kelada, Mark and Walsh, John M.D. and Devine, Robert and McArdle, Patrick and Stephens, John C. (2018) Synthesis of pyrazolopyrimidinones using a “one-pot” approach under microwave irradiation. Beilstein Journal of Organic Chemistry, 14. pp. 1222-1228. ISSN 1860-5397

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    Abstract

    A simple one-pot method for the microwave-assisted synthesis of substituted pyrazolo[1,5-a]pyrimidinones, a core scaffold in many bioactive and pharmaceutically relevant compounds, has been established. A variety of substituents was tolerated at the 2 and 5 positions, including functionalized aryls, heterocycles, and alkyl groups.

    Item Type: Article
    Additional Information: This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Cite as: Kelada, M.; Walsh, J. M. D.; Devine, R. W.; McArdle, P.; Stephens, J. C. Beilstein J. Org. Chem. 2018, 14, 1222–1228. doi:10.3762/bjoc.14.104
    Keywords: microwave-assisted synthesis; nitrogen-fused heterocycle; one-pot; pyrimidinone;
    Academic Unit: Faculty of Science and Engineering > Chemistry
    Item ID: 10745
    Identification Number: https://doi.org/10.3762/bjoc.14.104
    Depositing User: Dr John Stephens
    Date Deposited: 24 Apr 2019 13:59
    Journal or Publication Title: Beilstein Journal of Organic Chemistry
    Publisher: Beilstein-Institut
    Refereed: Yes
    URI:

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