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    A Cu(II) complex targeting the translocator protein: in vitro and in vivo antitumor potential and mechanistic insights


    Montagner, Diego and Fresch, B. and Browne, K. and Gandin, Valentina and Erxleben, Andrea (2017) A Cu(II) complex targeting the translocator protein: in vitro and in vivo antitumor potential and mechanistic insights. Chemical Communications, 53 (1). pp. 134-137. ISSN 1364-548X

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    Abstract

    A new Cu-based anticancer metallodrug which targets the translocator protein is reported. [CuBr2(TZ6)] elicits a remarkable in vitro cytotoxicity in sensitive and multidrug resistant cell lines and induces a 98% reduction of tumor mass in a murine tumor model. Target binding was studied by experimental and computational methods.

    Item Type: Article
    Keywords: Cu(II) complex; translocator protein; antitumor potential;
    Academic Unit: Faculty of Science and Engineering > Chemistry
    Item ID: 10753
    Identification Number: https://doi.org/10.1039/C6CC08100B
    Depositing User: Diego Montagner
    Date Deposited: 26 Apr 2019 14:00
    Journal or Publication Title: Chemical Communications
    Publisher: Royal Society of Chemistry
    Refereed: Yes
    URI:

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