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    Steroid–AuI–NHC Complexes: Synthesis and Antibacterial Activity


    Velle, Alba and Maguire, Ronan Cathal and Kavanagh, Kevin and Sanz Miguel, Pablo and Montagner, Diego (2017) Steroid–AuI–NHC Complexes: Synthesis and Antibacterial Activity. ChemMedChem, 12 (11). pp. 841-844. ISSN 1860-7187

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    Abstract

    A series of gold(I) pioneer complexes bearing N‐heterocyclic carbenes and steroid derivatives (ethynylestradiol and ethisterone) with the generic formula [Au(R2‐imidazol‐2‐ylidene)(steroid)] (where R=CH3 or CH2CH2OCH3) were synthesized, and the X‐ray structure of a rare of gold(I)–estradiol derivative is discussed. Toxicity studies reveal notable antibacterial activity of the gold‐based compounds, which is significantly increased in vivo by the presence of the estradiol unit. Toxicity profiling was estimated in vitro versus Gram‐positive (Staphylococcus aureus) and Gram‐negative (Escherichia coli) bacteria, and in vivo on Galleria mellonella larvae against E. coli.

    Item Type: Article
    Keywords: Steroid–AuI–NHC Complexes; Synthesis; Antibacterial Activity;
    Academic Unit: Faculty of Science and Engineering > Chemistry
    Item ID: 10754
    Identification Number: https://doi.org/10.1002/cmdc.201700257
    Depositing User: Diego Montagner
    Date Deposited: 26 Apr 2019 14:20
    Journal or Publication Title: ChemMedChem
    Publisher: Wiley
    Refereed: Yes
    URI:

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