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    Increased Cortical Nitric Oxide Release After Phencyclidine Administration


    Palsson, Erik and Finnerty, Niall J. and Fejgin, Kim and Klamer, Daniel and Wass, Caroline and Svensson, Lennart and Lowry, John P. (2009) Increased Cortical Nitric Oxide Release After Phencyclidine Administration. Synapse, 63. pp. 1083-1088. ISSN 1098-2396

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    Abstract

    Phencyclidine exerts psychotomimetic effects in humans and is used as a pharmacological animal model for schizophrenia. We, and others, have demonstrated that phencyclidine induces cognitive deficits in rats that are associated with schizophrenia. These cognitive deficits can be normalized by inhibition of nitric oxide synthase. The development of selective microelectrochemical nitric oxide sensors may provide direct evidence for the involvement of nitric oxide in these effects. The aim of the present study was to use LIVE (long term in vivo electrochemistry) to investigate the effect of phencyclidine, alone or in combination with the nitric oxide synthase inhibitor L-NAME, on nitric oxide levels in the medial prefrontal cortex of freely moving rats. Phencyclidine (2 mg kg21) produced an increase in cortical nitric oxide levels and this increase was ameliorated by L-NAME (10 mg kg21). Tentatively, the results from the present study provide a biochemical rationale for the involvement of nitric oxide in the phencyclidine model of schizophrenia.

    Item Type: Article
    Keywords: rat; schizophrenia; in vivo voltammetry; cognition;
    Academic Unit: Faculty of Science and Engineering > Chemistry
    Item ID: 10764
    Identification Number: https://doi.org/10.1002/syn.20690
    Depositing User: Niall Finnerty
    Date Deposited: 30 Apr 2019 14:37
    Journal or Publication Title: Synapse
    Publisher: Wiley
    Refereed: Yes
    URI:

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