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    Bioreductive fluorescent imaging agents: applications to tumour hypoxia


    Elmes, Robert B.P. (2016) Bioreductive fluorescent imaging agents: applications to tumour hypoxia. Chemical Communications, 52. pp. 8935-8956. ISSN 1359-7345

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    Abstract

    Large tumours contain regions with very low intracellular O2 concentrations. Known as hypoxia, this feature of tumours yields a highly reducing environment owing to the presence of numerous oxygen sensitive reductase enzymes. The development of new optical chemosensors for these various reductases presents an ideal approach to visualise areas of hypoxia or highly reducing environments. Critical to the success of such chemosensors is the design of probes containing a bioreductively activated moiety that either ensures the selective retention of fluorescence within a hypoxic tissue or a probe that irreversibly releases a reporter fluorophore. This Feature Article aims to summarise the fluorescent tools that have been developed to image tumour hypoxia and the various reductase enzymes associated with the bioreduction process.

    Item Type: Article
    Keywords: Bioreductive fluorescent imaging agents; tumour hypoxia; imaging; flourescent tools;
    Academic Unit: Faculty of Science and Engineering > Chemistry
    Item ID: 10768
    Identification Number: https://doi.org/10.1039/C6CC01037G
    Depositing User: Robert Elmes
    Date Deposited: 03 May 2019 13:50
    Journal or Publication Title: Chemical Communications
    Publisher: Royal Society of Chemstry
    Refereed: Yes
    URI:

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