Martínez-Calvo, Miguel and Orange, Kim N. and Elmes, Robert B.P. and la Cour Poulsen, Bjørn and Williams, D. Clive and Gunnlaugsson, Thorfinnur
(2016)
Ru(II)-polypyridyl surface functionalised gold nanoparticles as DNA targeting supramolecular structures and luminescent cellular imaging agents.
Nanoscale, 8.
pp. 563-574.
ISSN 2040-3372
Abstract
The development of Ru(II) functionalized gold nanoparticles 1–3·AuNP is described. These systems were found to be mono-disperse with a hydrodynamic radius of ca. 15 nm in water but gave rise to the formation of higher order structures in buffered solution. The interaction of 1–3·AuNP with DNA was also studied by spectroscopic and microscopic methods and suggested the formation of large self-assembly structures in solution. The uptake of 1–3·AuNP by cancer cells was studied using both confocal fluorescence as well as transmission electron microscopy (TEM), with the aim of investigating their potential as tools for cellular biology. These systems displaying a non-toxic profile with favourable photophysical properties may have application across various biological fields including diagnostics and therapeutics.
| Item Type: |
Article
|
| Keywords: |
Ru(II)-polypyridyl surface functionalised gold nanoparticles; DNA targeting supramolecular structures; luminescent cellular imaging agents; |
| Academic Unit: |
Faculty of Science and Engineering > Chemistry |
| Item ID: |
10769 |
| Identification Number: |
https://doi.org/10.1039/C5NR05598A |
| Depositing User: |
Robert Elmes
|
| Date Deposited: |
03 May 2019 15:07 |
| Journal or Publication Title: |
Nanoscale |
| Publisher: |
Royal Society of Chemistry |
| Refereed: |
Yes |
| Funders: |
Science Foundation Ireland (SFI), Ministerio of Economía y Competitividad of Spain, Irish Research Council for Science, Engineering and Technology (IRCSET) |
| URI: |
|
| Use Licence: |
This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available
here |
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