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    Ru(II)-polypyridyl surface functionalised gold nanoparticles as DNA targeting supramolecular structures and luminescent cellular imaging agents


    Martínez-Calvo, Miguel and Orange, Kim N. and Elmes, Robert B.P. and la Cour Poulsen, Bjørn and Williams, D. Clive and Gunnlaugsson, Thorfinnur (2016) Ru(II)-polypyridyl surface functionalised gold nanoparticles as DNA targeting supramolecular structures and luminescent cellular imaging agents. Nanoscale, 8. pp. 563-574. ISSN 2040-3372

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    Abstract

    The development of Ru(II) functionalized gold nanoparticles 1–3·AuNP is described. These systems were found to be mono-disperse with a hydrodynamic radius of ca. 15 nm in water but gave rise to the formation of higher order structures in buffered solution. The interaction of 1–3·AuNP with DNA was also studied by spectroscopic and microscopic methods and suggested the formation of large self-assembly structures in solution. The uptake of 1–3·AuNP by cancer cells was studied using both confocal fluorescence as well as transmission electron microscopy (TEM), with the aim of investigating their potential as tools for cellular biology. These systems displaying a non-toxic profile with favourable photophysical properties may have application across various biological fields including diagnostics and therapeutics.

    Item Type: Article
    Keywords: Ru(II)-polypyridyl surface functionalised gold nanoparticles; DNA targeting supramolecular structures; luminescent cellular imaging agents;
    Academic Unit: Faculty of Science and Engineering > Chemistry
    Item ID: 10769
    Identification Number: https://doi.org/10.1039/C5NR05598A
    Depositing User: Robert Elmes
    Date Deposited: 03 May 2019 15:07
    Journal or Publication Title: Nanoscale
    Publisher: Royal Society of Chemistry
    Refereed: Yes
    Funders: Science Foundation Ireland (SFI), Ministerio of Economía y Competitividad of Spain, Irish Research Council for Science, Engineering and Technology (IRCSET)
    URI:

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