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    A cysteine sensor based on a gold nanoparticle–iron phthalocyanine modified graphite paste electrode


    Abbas, Mohammed Noredeen and Saeed, Ayman Ali and Singh, Baljit and Radowan, Abdellatef A. and Dempsey, Eithne (2015) A cysteine sensor based on a gold nanoparticle–iron phthalocyanine modified graphite paste electrode. Analytical Methods, 7 (6). 2529 -2536. ISSN 1759-9660

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    Abstract

    An electrochemical sensor for the sensitive and selective detection of cysteine is proposed based on a gold nanoparticle (AuNP)–iron(III) phthalocyanine (FePc) modified graphite paste electrode. The sensor was characterised using scanning electron microscopy (SEM/EDX), transmission electron microscopy (TEM), cyclic voltammetry and electrochemical impedance spectroscopy (EIS). Cyclic voltammetry studies demonstrated that the electrochemical behaviour of cysteine at the AuNP–FePc modified graphite paste electrode is considerably improved compared to both the blank (unmodified) and FePc-modified graphite paste electrodes. The enhancement of the anodic redox signal for cysteine was due to a catalytic effect of gold nanoparticles which was investigated using three different graphite paste electrodes − 0.02, 0.055 and 0.11 wt% Au nanoparticles, each with a fixed quantity of FePc (5 wt%). The sensor fabricated using 0.055 wt% AuNPs exhibited optimum sensitivity as examined via differential pulse voltammetry measurements with an analytical range of 50–1000 μM and a LOD of 0.27 μM. The sensor was utilised for the determination of cysteine in pharmaceutical preparations.

    Item Type: Article
    Keywords: Voltammetric Determination; Electrochemical Determination; Electrocatalytic Transducer; Diamond Electrodes; Carbon Nanotubes; Absorbic Acid; Oxidation; Film; Nanocomposities; Methionine;
    Academic Unit: Faculty of Science and Engineering > Chemistry
    Item ID: 12524
    Identification Number: https://doi.org/10.1039/C4AY02944E
    Depositing User: Eithne Dempsey
    Date Deposited: 05 Mar 2020 16:53
    Journal or Publication Title: Analytical Methods
    Publisher: Royal Society of Chemistry
    Refereed: Yes
    URI:

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