Sibson, Nicola R. and McHugh, S. and Lowry, John P. (2009) Combined fMRI and metabolic voltammetry in vivo: understanding the neurochemical basis of functional imaging signals. Journal of Cerebral Blood Flow & Metabolism, 29 (1_Supp). pp. 613-614. ISSN 0271-678X

Preview

Download (805kB) | Preview

Abstract

Objectives:The use of functional magnetic resonance imaging (fMRI) in both basic and clinical neuroscience is rapidly expanding. However, although advance shave been made in correlating fMRI responses with the underlying neuronal activity, the fact remains that this technique does not directly measure neuronal activity but associated haemodynamic (and metabolic)events. Moreover, a constant relationship between neuronal, haemodynamic and metabolic processes across different brain regions is frequently assumed,despite substantial differences in neuronal architecture.Only by fully understanding the relationship between these parameters will we be able to fully utilise functional neuroimaging. Therefore, we must find away of correlating fMRI data, which largely reflects the haemodynamic component,with neural and/or meta-bolic information. Long-term in-vivo electrochemistry(LIVE) enables real-time measurement of brain metabolites.1In this study we have developed methods for simultaneous fMRI and tissue oxygen measurements via LIVE for direct correlation of metabolic and haemodynamic factors...

Item Type:	Article
Keywords:	Brain Imaging; MRI/fMRI;
Academic Unit:	Faculty of Science and Engineering > Chemistry
Item ID:	12549
Identification Number:	https://doi.org/10.1038/jcbfm.2009.172
Depositing User:	John Lowry
Date Deposited:	09 Mar 2020 16:56
Journal or Publication Title:	Journal of Cerebral Blood Flow & Metabolism
Publisher:	SAGE Publications
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

Repository Staff Only(login required)

Item control page

Downloads

Origin of downloads