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    Increased immune cell infiltration in patient-derived tumor explants treated with Traniplatin: an original Pt(iv) pro-drug based on Cisplatin and Tranilast


    Lo Re, Daniele and Montagner, Diego and Tolan, Dina and Di Sanza, Claudio and Iglesias, Mar and Calon, Alexandre and Giralt, Ernest (2018) Increased immune cell infiltration in patient-derived tumor explants treated with Traniplatin: an original Pt(iv) pro-drug based on Cisplatin and Tranilast. Chemical Communications, 54 (60). pp. 8324-8327. ISSN 1359-7345

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    Abstract

    Elevated intra-tumoral immune infiltrate is associated with an improved prognosis in cancer of distinct origins. Traniplatin (TPT) is a novel platinum(IV) pro-drug based on Cisplatin (CDDP) and the marketed drug Tranilast. When compared in vitro to Cisplatin, TPT showed increased cytotoxic activity against colon and lung cancer cells but decreased activity against immune cells. In addition, TPT efficiency was evaluated in tumor explants derived from colorectal cancer samples from patients subjected to intended curative surgery. TPT induced strong intra-tumoral cytotoxic activity yet was associated with an elevated presence of immune cell infiltrate, suggesting a reduced cytotoxic activity against immune cells in colorectal cancer.

    Item Type: Article
    Keywords: Cancer Cells; Stage II; Platinum; Complexes; Satraplatin; Survival; Localization; Mechanisms; Expression; Resistance;
    Academic Unit: Faculty of Science and Engineering > Chemistry
    Item ID: 12579
    Identification Number: https://doi.org/10.1039/C8CC02071J
    Depositing User: Diego Montagner
    Date Deposited: 20 Mar 2020 11:12
    Journal or Publication Title: Chemical Communications
    Publisher: Royal Society of Chemstry
    Refereed: Yes
    URI:

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