Timofte, Roxana S. and Titman, Jeremy J. and Shao, Limin and Stephens, John C. and Woodward, Simon (2005) Investigations into the utility of high-​surface area silica pellets as potential solid-​phase synthesis supports. Tetrahedron, 65 (1). pp. 51-59. ISSN 0040-4020

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Abstract

Grace-Davidson silica pellets (SMR-057-015) are found to be optimal for surface grafting of (RO)3Si(CH2)3FG reagents. While loadings of up to 2.1 mmol g−1 can be attained (ca. 0.05 mmol per pellet) access of further reagents to the graft sites is problematic above loadings of 0.8 mmol g−1. 13C CPMAS NMR studies may be carried out on individual pellets (using natural abundance substrates) and the resulting spectra are diagnostic in identifying successful subsequent coupling reactions. Sequential synthesis can be attained on mesoporous silica pellets and monitored by solid-state 13C NMR spectroscopy.

Item Type:	Article
Keywords:	Supported reagents; Silica; Coupling reactions;
Academic Unit:	Faculty of Science and Engineering > Chemistry
Item ID:	12588
Identification Number:	https://doi.org/10.1016/j.tet.2004.10.064
Depositing User:	Dr John Stephens
Date Deposited:	23 Mar 2020 12:16
Journal or Publication Title:	Tetrahedron
Publisher:	Elsevier
Refereed:	Yes
URI:	Publisher

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