Cleary-Gaffney, Michael and Coogan, Andrew (2018) Limited evidence for affective and diurnal rhythm responses to dim light-at-light in male and female C57Bl/6 mice. Physiology & Behavior, 189. pp. 78-85. ISSN 0031-9384/

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Abstract

Circadian rhythms are recurring patterns in a range of behavioural, physiological and molecular parameters that display periods of near 24 h, and are underpinned by an endogenous biological timekeeping system. Circadian clocks are increasingly recognised as being key for health. Environmental light is the key stimulus that synchronises the internal circadian system with the external time cues. There are emergent health concerns regarding increasing worldwide prevalence of electric lighting, especially man-made light-at-night, and light's impact on the circadian system may be central to these effects. A number of previous studies have demonstrated increased depression-like behaviour in various rodent experimental models exposed to dim light-at-night. In this study we set out to study the impact of dim light-at-night on circadian and affective behaviours in C57Bl/6 mice. We set out specifically to examine the impact of sex on light at night's effects, as well as the impact of housing conditions. We report minimal impact of light-at-night on circadian and affective behaviours, as measured by the tail suspension test, the forced swim test, the sucrose preference test and the elevated plus maze. Light-at-night was also not associated with an increase in body weight, but was associated with a decrease in the cell proliferation marker Ki-67 in the dentate gyrus. In summary, we conclude that experimental contextual factors, such as model species or strain, may be considerable importance in the investigation of the impact of light at night on mood-related parameters

Item Type:	Article
Keywords:	Circadian; Light-at-night; Mood; Mouse; Ki-67;
Academic Unit:	Faculty of Science and Engineering > Psychology
Item ID:	13066
Identification Number:	https://doi.org/10.1016/j.physbeh.2018.03.010
Depositing User:	Dr. Andrew Coogan
Date Deposited:	18 Jun 2020 14:48
Journal or Publication Title:	Physiology & Behavior
Publisher:	Elsevier
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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