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    ADHD 24/7: Circadian Clock Genes, Chronotherapy and Sleep/Wake Cycle Insufficiencies in ADHD


    Korman, Maria and Palm, Denise and Uzoni, Adriana and Faltraco, Frank and Tucha, Oliver and Thome, Johannes and Coogan, Andrew (2018) ADHD 24/7: Circadian Clock Genes, Chronotherapy and Sleep/Wake Cycle Insufficiencies in ADHD. The World Journal of Biological Psychiatry, 21 (3). pp. 1-35. ISSN 1562-2975

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    Abstract

    The current paper addresses the evidence for circadian clock characteristics associated with Attention-Deficit Hyperactivity Disorder (ADHD), and possible therapeutic approaches based on chronomodulation through bright light therapy. Methods: We review the data reported in ADHD on genetic risk factors for phase-delayed circadian rhythms and on the role of photic input in circadian re-alignment. Results: Single nucleotide polymorphisms (SNPs) in circadian genes were recently associated with core ADHD symptoms, increased evening-orientation and frequent sleep problems. Additionally, alterations in exposure and response to photic input may underlie circadian problems in ADHD. Bright light (BL) therapy was shown to be effective for re-alignment of circadian physiology toward morningness, reducing sleep disturbances and bringing overall improvement in ADHD symptoms. The susceptibility of the circadian system to phase shift by timed BL exposure may have broad cost-effective potential implications for the treatment of ADHD. Conclusions: We conclude that further research of circadian function in ADHD should focus on detection of genetic markers (e.g., using human skin fibroblasts) and development of BL-based therapeutic interventions.

    Item Type: Article
    Additional Information: This is the preprint version of the published article, which is available at The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry, 05 Nov 2018, :1-16 DOI: 10.1080/15622975.2018.1523565
    Keywords: Attention-Deficit Hyperactivity Disorder; Chronotype; Circadian Genes; Light Therapy; Fibroblasts;
    Academic Unit: Faculty of Science and Engineering > Psychology
    Item ID: 13067
    Identification Number: https://doi.org/10.1080/15622975.2018.1523565
    Depositing User: Dr. Andrew Coogan
    Date Deposited: 18 Jun 2020 15:13
    Journal or Publication Title: The World Journal of Biological Psychiatry
    Publisher: Informa Healthcare
    Refereed: Yes
    URI:

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