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    Coumarin-based fluorescent ‘AND’ logic gate probes for the detection of homocysteine and a chosen biological analyte


    Wu, Luling and Gardiner, Jordan E. and Kumawat, Lokesh Kumar and Han, Hai-Hao and Guo, Ruiying and Li, Xin and He, Xiao-Peng and Elmes, Robert B.P. and Sedgwick, Adam C. and Bull, Steven D and James, Tony D. (2019) Coumarin-based fluorescent ‘AND’ logic gate probes for the detection of homocysteine and a chosen biological analyte. RSC Advances, 9. pp. 26425-26428. ISSN 2046-2069

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    Abstract

    With this research we set out to develop a number of coumarin-based ‘AND’ logic fluorescence probes that were capable of detecting a chosen analyte in the presence of HCys. Probe JEG-CAB was constructed by attaching the ONOO� reactive unit, benzyl boronate ester, to a HCys/Cys reactive fluorescent probe, CAH. Similarly, the core unit CAH was functionalised with the nitroreductase (NTR) reactive p-nitrobenzyl unit to produce probe JEG-CAN. Both, JEG-CAB and JEG-CAN exhibited a significant fluorescence increase when exposed to either HCys and ONOO� (JEG-CAB) or HCys and NTR (JEG-CAN) thus demonstrating their effectiveness to function as AND logic gates for HCys and a chosen analyte.

    Item Type: Article
    Keywords: Coumarin-based fluorescent; logic gate; probes; detection; homocysteine; chosen; biological analyte;
    Academic Unit: Faculty of Science and Engineering > Chemistry
    Item ID: 13853
    Identification Number: https://doi.org/10.1039/C9RA04908H
    Depositing User: Robert Elmes
    Date Deposited: 22 Jan 2021 11:10
    Journal or Publication Title: RSC Advances
    Publisher: Royal Society of Chemistry
    Refereed: Yes
    URI:

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