Branagan, David and Breslin, Carmel B.
(2019)
Electrochemical detection of glucose at physiological pH using gold nanoparticles deposited on carbon nanotubes.
Sensors and Actuators B: Chemical, 282.
pp. 490-499.
ISSN 0925-4005
Abstract
There is currently considerable interest in the development of non–enzymatic glucose sensors and gold is one of
the noble metals that enables the oxidation of glucose. Gold nanoparticles with a mean diameter of 7.5 nm were
deposited onto the walls of functionalised carbon nanotubes to give a gold loading of 2.0% by weight. This
composite was dispersed and cast onto glassy carbon and carbon screen printed electrodes. These electrodes
were then used to detect glucose in a neutral phosphate buffer solution, corresponding to physiological pH.
Using constant potential amperometry, a linear calibration curve was obtained with a sensitivity of
2.77 ± 0.14 μA/mM, a limit of detection, LOD, of 4.1 μM and a linear region extending to 25 mM. This sensor
showed very good selectivity in the presence of ascorbic acid, galactose and fructose, but interference was
observed in the presence of uric acid. This interference was eliminated by applying a Nafion® film to the
composite electrodes. Due to a lower diffusion of glucose across the Nafion® barrier, the sensitivity of the Nafion®
coated composite was reduced to 0.55 ± 0.03 μA/mM and the LOD was increased to 10.0 μM. However, a linear
response between 0.1mM and 25mM was obtained, which covers the normal and elevated levels of glucose in
blood. These sensors showed very good stability when stored in air and it was also possible to re–use the sensors.
| Item Type: |
Article
|
| Additional Information: |
Cite as: David Branagan, Carmel B. Breslin,
Electrochemical detection of glucose at physiological pH using gold nanoparticles deposited on carbon nanotubes,
Sensors and Actuators B: Chemical,
Volume 282,
2019,
Pages 490-499,
ISSN 0925-4005,
https://doi.org/10.1016/j.snb.2018.11.089 |
| Keywords: |
Carbon nanotubes; Gold nanoparticles;
Nanocomposite; Glucose sensor; non–enzymatic;
Physiological pH; |
| Academic Unit: |
Faculty of Science and Engineering > Chemistry |
| Item ID: |
14141 |
| Identification Number: |
https://doi.org/10.1016/j.snb.2018.11.089 |
| Depositing User: |
Dr. Carmel Breslin
|
| Date Deposited: |
09 Mar 2021 14:24 |
| Journal or Publication Title: |
Sensors and Actuators B: Chemical |
| Publisher: |
Elsevier |
| Refereed: |
Yes |
| URI: |
|
| Use Licence: |
This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available
here |
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