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Ahmed, Muhib, Rooney, A. Denise, McCann, Malachy, Casey, Jamie, O'Shea, Katie and Twanley, Brendan (2019) Tuning the reaction pathways of phenanthroline-Schiff bases: routes to novel phenanthroline ligands. Dalton Transactions, 48. pp. 15283-15289. ISSN 1477-9226
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Abstract
Pyrido-phenanthrolin-7-one compounds are structural analogues of the cytotoxic alkaloid, ascididemin,
and would be expected to have interesting biological activities. Synthetic strategies are reported for a novel
simple route to form this class of ligand. 1,10-Phenanthrolin-5,6-dione reacts with L-phenylalanine alkyl
esters and their para-substituted analogues to form both a phenanthroline–oxazine and a pyrido-phenanthrolin-
7-one product. The nature of the major product is dependent on the electronic properties of the
para substituent. Successful metal coordination to the pyrido-phenanthrolin-7-one ligand is also presented.
| Item Type: | Article |
|---|---|
| Additional Information: | Cite as: Dalton Trans., 2019,48, 15283-15289 |
| Keywords: | Tuning; reaction; pathways; phenanthroline- Schiff bases; routes; novel; phenanthroline ligands; |
| Academic Unit: | Faculty of Science and Engineering > Chemistry |
| Item ID: | 14519 |
| Identification Number: | 10.1039/C9DT03084K |
| Depositing User: | Dr. Denise Rooney |
| Date Deposited: | 09 Jun 2021 13:59 |
| Journal or Publication Title: | Dalton Transactions |
| Publisher: | Royal Society of Chemistry |
| Refereed: | Yes |
| Related URLs: | |
| Use Licence: | This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here |
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