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    Viruses and the human DEAD-box helicase DDX3: inhibition or exploitation?


    Schroeder, Martina (2011) Viruses and the human DEAD-box helicase DDX3: inhibition or exploitation? Biochemical Society Transactions, 39 (2). pp. 679-683. ISSN 0300-5127

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    Abstract

    Human DDX3 is a DEAD (Asp-Glu-Ala-Asp)-box RNA helicase that appears to be a prime target for viral manipulation. While two viruses that manifest major global health threats, HIV and HCV (hepatitis C virus), utilize DDX3 for their replication, other viruses inhibit DDX3’s newly identified function in innate antiviral signalling. This review discusses the role of DDX3 in antiviral immunity and its inhibition or exploitation by different viruses.

    Item Type: Article
    Additional Information: The definitive version of this article is available at doi:10.1042/BST0390679 . Work in my laboratory is supported by Science Foundation Ireland [grant number 09/RFP/BIC2188] and the Irish Health Research Board [grant numbers HRA/2009/171 and PD/2007/35].
    Keywords: Viruses; human DEAD-box helicase DDX3; viral manipulation; Martina Schröder;
    Academic Unit: Faculty of Science and Engineering > Research Institutes > Institute of Immunology
    Item ID: 4064
    Depositing User: Martina Schroeder
    Date Deposited: 09 Jan 2013 15:11
    Journal or Publication Title: Biochemical Society Transactions
    Publisher: Portland Press
    Refereed: Yes
    Funders: Science Foundation Ireland, Irish Health Research Board
    URI:

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