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    Multivalent glycoconjugates as anti-pathogenic agents


    Bernardi, Anna and Jimenez-Barbero, Jesus and Casnati, Alessandro and De Castro, Chritina and Darbre, Tamis and Fieschi, Franck and Finne, Jukka and Funken, Horst and Jaeger, Karl-Erich and Lahmann, Martina and Lindhorst, Thisbe K. and Marradi, Marco and Messner, Paul and Molinaro, Antonio and Murphy, Paul V. and Nativi, Cristina and Oscarson, Stefan and Penades, Soledad and Peri, Francesco and Pieters, Roland J. and Renaudet, Olivier and Reymond, Jean-Reymond and Richichi, Barbara and Rojo, Javier and Sansone, Francesco and Schaffer, Christina and Turnbull, W. Bruce and Velasco-Torrijos, Trinidad and Vidal, Sebastien and Vincent, Stephane and Wennekes, Tom and Zuilhof, Han and Imberty, Anne (2012) Multivalent glycoconjugates as anti-pathogenic agents. Chemical Society Reviews (Advance article). pp. 1-28. ISSN 0306-0012

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    Abstract

    Multivalency plays a major role in biological processes and particularly in the relationship between pathogenic microorganisms and their host that involves protein–glycan recognition. These interactions occur during the first steps of infection, for specific recognition between host and bacteria, but also at different stages of the immune response. The search for high-affinity ligands for studying such interactions involves the combination of carbohydrate head groups with different scaffolds and linkers generating multivalent glycocompounds with controlled spatial and topology parameters. By interfering with pathogen adhesion, such glycocompounds including glycopolymers, glycoclusters, glycodendrimers and glyconanoparticles have the potential to improve or replace antibiotic treatments that are now subverted by resistance. Multivalent glycoconjugates have also been used for stimulating the innate and adaptive immune systems, for example with carbohydrate-based vaccines. Bacteria present on their surfaces natural multivalent glycoconjugates such as lipopolysaccharides and S-layers that can also be exploited or targeted in anti-infectious strategies

    Item Type: Article
    Additional Information: Part of the Multivalent Scaffolds in Glycosciences themed issue. The definitive version of this article is available at DOI:10.1039/C2CS35408J
    Keywords: Multivalent; glycoconjugates; anti-pathogenic agents; microorganisms;
    Academic Unit: Faculty of Science and Engineering > Chemistry
    Item ID: 4256
    Depositing User: Dr. Trinidad Velasco-Torrijos
    Date Deposited: 13 Mar 2013 17:02
    Journal or Publication Title: Chemical Society Reviews
    Publisher: Royal Society of Chemistry
    Refereed: Yes
    URI:

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