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    Language processing abnormalities in adolescents with psychotic-like experiences: An event related potential study


    Murphy, Jennifer and Blanchard, Mathieu M. and Rawdon, Caroline and Kavanagh, Fergal and Kelleher, Ian and Clarke, Mary C. and Roche, Richard and Cannon, Mary (2012) Language processing abnormalities in adolescents with psychotic-like experiences: An event related potential study. Schizophrenia Research, 137. pp. 91-96. ISSN 0920-9964

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    Abstract

    Language impairments are a well established finding in patients with schizophrenia and in individuals at-risk for psychosis. A growing body of research has revealed shared risk factors between individuals with psychotic-like experiences (PLEs) from the general population and patients with schizophrenia. In particular, adolescents with PLEs have been shown to be at an increased risk for later psychosis. However, to date there has been little information published on electrophysiological correlates of language comprehension in this at-risk group. A 64 channel EEG recorded electrical activity while 37 (16 At-Risk; 21 Controls) participants completed the British Picture Vocabulary Scale (BPVS-II) receptive vocabulary task. The P300 component was examined as a function of language comprehension. The at-risk group were impaired behaviourally on receptive language and were characterised by a reduction in P300 amplitude relative to the control group. The results of this study reveal electrophysiological evidence for receptive language deficits in adolescents with PLEs, suggesting that the earliest neurobiological changes underlying psychosis may be apparent in the adolescent period.

    Item Type: Article
    Additional Information: The definitive version of this article is available at DOI: 10.1016/j.schres.2012.01.017
    Keywords: Psychosis; P300; Psychotic-like experiences; Schizophrenia; Language; PLEs;
    Academic Unit: Faculty of Science and Engineering > Psychology
    Item ID: 6796
    Identification Number: https://doi.org/10.1016/j.schres.2012.01.017
    Depositing User: Richard Roche
    Date Deposited: 14 Jan 2016 10:51
    Journal or Publication Title: Schizophrenia Research
    Publisher: Elsevier
    Refereed: Yes
    URI:

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