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    Synthesis and photophysical evaluations of fluorescent quaternary bipyridyl-1,8-naphthalimide conjugates as nucleic acid targeting agents


    Ryan, Gary J. and Elmes, Robert B.P. and Quinn, Susan J. and Gunnlaugsson, Thorfinnur (2012) Synthesis and photophysical evaluations of fluorescent quaternary bipyridyl-1,8-naphthalimide conjugates as nucleic acid targeting agents. Supramolecular Chemistry, 24 (3). pp. 175-188. ISSN 1061-0278

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    Abstract

    A family of organic molecules containing the DNA intercalating chromophores, 4-nitro- and 4-amino 1,8-naphthalamide, conjugated to a diquat derivative by an ‘orthogonal’ phenyl spacer have been prepared, and characterized. Their binding interactions with double-stranded DNA was studied by a variety of spectroscopic techniques. These charged organic compounds are found to exhibit excellent binding affinities to DNA with binding constants comparable to those exhibited by metal complexes.

    Item Type: Article
    Additional Information: This is the preprint version of the published article, which is available at DOI: 10.1080/10610278.2011.638381
    Keywords: DNA probes; naphthalimide; fluorescence; sensors; supramolecular systems;
    Academic Unit: Faculty of Science and Engineering > Chemistry
    Item ID: 6992
    Identification Number: https://doi.org/10.1080/10610278.2011.638381
    Depositing User: Robert Elmes
    Date Deposited: 26 Feb 2016 16:56
    Journal or Publication Title: Supramolecular Chemistry
    Publisher: Taylor & Francis
    Refereed: Yes
    Funders: Science Foundation Ireland (SFI), Irish Research Council for Science Engineering and Technology (IRCSET)
    URI:

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