Elmes, Robert B.P. and Erby, Marialuisa and Cloonan, Suzanne M. and Quinn, Susan J. and Williams, D. Clive and Gunnlaugsson, Thorfinnur (2011) Quaternarized pdppz; a novel dppz derivative that causes cellular death upon light irradiation: Synthesis, DNA-binding and biological studies. Chemical Communications, 47. pp. 686-688. ISSN 1359-7345

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Abstract

The quaternarized pdppz derivative 1 was shown to bind strongly to DNA with concomitant changes in its ground and excited state photophysical properties. Furthermore, the compound also showed rapid cellular uptake, and induced apoptosis upon light irradiation in various cancer cell lines after 24 hours of incubation.

Item Type:	Article
Keywords:	Quaternarized pdppz; novel dppz derivative; cellular death; light irradiation; Synthesis; DNA-binding; biological studies;
Academic Unit:	Faculty of Science and Engineering > Chemistry
Item ID:	6994
Identification Number:	https://doi.org/10.1039/c0cc04303f
Depositing User:	Robert Elmes
Date Deposited:	26 Feb 2016 16:56
Journal or Publication Title:	Chemical Communications
Publisher:	Royal Society of Chemistry
Refereed:	Yes
Funders:	Science Foundation Ireland (SFI), Higher Education Authority (HEA), Irish Research Council for Science Engineering and Technology (IRCSET)
URI:	http://pubs.rsc.org/
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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