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    Quaternarized pdppz; a novel dppz derivative that causes cellular death upon light irradiation: Synthesis, DNA-binding and biological studies


    Elmes, Robert B.P. and Erby, Marialuisa and Cloonan, Suzanne M. and Quinn, Susan J. and Williams, D. Clive and Gunnlaugsson, Thorfinnur (2011) Quaternarized pdppz; a novel dppz derivative that causes cellular death upon light irradiation: Synthesis, DNA-binding and biological studies. Chemical Communications, 47. pp. 686-688. ISSN 1359-7345

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    Abstract

    The quaternarized pdppz derivative 1 was shown to bind strongly to DNA with concomitant changes in its ground and excited state photophysical properties. Furthermore, the compound also showed rapid cellular uptake, and induced apoptosis upon light irradiation in various cancer cell lines after 24 hours of incubation.

    Item Type: Article
    Keywords: Quaternarized pdppz; novel dppz derivative; cellular death; light irradiation; Synthesis; DNA-binding; biological studies;
    Academic Unit: Faculty of Science and Engineering > Chemistry
    Item ID: 6994
    Identification Number: https://doi.org/10.1039/c0cc04303f
    Depositing User: Robert Elmes
    Date Deposited: 26 Feb 2016 16:56
    Journal or Publication Title: Chemical Communications
    Publisher: Royal Society of Chemistry
    Refereed: Yes
    Funders: Science Foundation Ireland (SFI), Higher Education Authority (HEA), Irish Research Council for Science Engineering and Technology (IRCSET)
    URI:

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