Aim: To examine psychosocial adjustment in persons with lower limb amputations related to diabetes. Methods: Thirty-eight participants with diabetes-related lower limb amputations, recruited from two limb-fitting centres, completed three psychological self-report assessments: the Trinity Amputation and Prosthesis Experience Scales (TAPES); the Hospital Anxiety and Depression Scale (HADS); and the Amputation Body Image Scale—Revised (ABIS-R). Results Over 18%of participants scored above the normal range (> 8) for depression on the HADS and 18.5% scored above the normal range for anxiety. Both depression (q = 0.75, P < 0.01) and anxiety (q = 0.62, P < 0.01) scores were significantly associated with body image disturbance, as measured using the ABIS-R. Significant relationships were also observed between body image disturbance and three TAPES subscales measuring psychosocial adjustment [general adjustment (q = )0.48, P < 0.01), social adjustment (q = )0.51, P < 0.01), adjustment to limitations (q = )0.45, P < 0.05)]. Conclusions: Individuals with diabetes-related amputations maybe at elevated risk for psychological distress as a result of their co-morbid medical condition. Regular screening for anxiety and depression and the provision of appropriate follow-up care may therefore be advisable in this population.