MURAL - Maynooth University Research Archive Library



    Role of the Phosphine Ligands on the Stabilization of Monoadducts of the Model Nucleobases 1-Methylcytosine and 9-Methylguanine in Platinum(II) Complexes


    Montagner, Diego and Zangrando, Ennio and Longato, Bruno (2008) Role of the Phosphine Ligands on the Stabilization of Monoadducts of the Model Nucleobases 1-Methylcytosine and 9-Methylguanine in Platinum(II) Complexes. Inorganic Chemistry, 47 (7). pp. 2688-2695. ISSN 0020-1669

    [img]
    Preview
    Download (966kB) | Preview


    Share your research

    Twitter Facebook LinkedIn GooglePlus Email more...



    Add this article to your Mendeley library


    Abstract

    The addition of 1-methylcytosine (1-MeCy) or 9-methylguanine (9-MeGu) to solutions of cis-(PPh3)2Pt(ONO2)2 (1a), in a molar ratio of 1:1, affords the monoadducts cis-[(PPh3)2Pt(1-MeCy)(ONO2)]NO3 (2a) and cis-[(PPh3)2Pt(9-MeGu)(ONO2)]NO3 (3a) and only trace amounts of the bisadducts cis-[(PPh3)2Pt(1-MeCy)2](NO3)2 (4a) and cis-[(PPh3)2Pt(9-MeGu)2](NO3)2 (5a), respectively. The X-ray structural determination of 2a and 3a indicates a strong π−π stacking interaction between one of the PPh3 phenyl groups and the pyrimydinic N3-platinated cytosine or the imidazole part of the N7-coordinated guanine base. The addition of a further equiv of nucleobase to the monoadducts forms quantitatively the bisadducts that have been isolated as pure compounds 4a and 5a. Under the same experimental conditions, the dinitrato analogue cis-[(PMePh2)2Pt(ONO2)2] (1b) forms the monoadducts 2b and 3b in equilibrium with a relatively high concentration (20–30%) of the bisadducts cis-[(PMePh2)2Pt(1-MeCy)2](NO3)2 (4b) and cis-[(PMePh2)2Pt(9-MeGu)2](NO3)2 (5b), which have been structurally characterized by single-crystal X-ray analysis. The characterization of the isolated complexes by multinuclear NMR spectroscopy is also described.

    Item Type: Article
    Keywords: Phosphine Ligands; Stabilization; Monoadducts; Model Nucleobases; 1-Methylcytosine; 9-Methylguanine;Platinum(II) Complexes;
    Academic Unit: Faculty of Science and Engineering > Chemistry
    Item ID: 7040
    Identification Number: https://doi.org/10.1021/ic7020319
    Depositing User: Diego Montagner
    Date Deposited: 21 Mar 2016 17:47
    Journal or Publication Title: Inorganic Chemistry
    Publisher: American Chemical Society
    Refereed: Yes
    URI:

    Repository Staff Only(login required)

    View Item Item control page

    Downloads

    Downloads per month over past year