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    Synthesis, Characterisation and Antifungal Activity of Copper(II)-Functionalised Silicone Polymers and Silicone-Coated Magnetic Nanoparticles


    Reynolds, Collette Regina (2015) Synthesis, Characterisation and Antifungal Activity of Copper(II)-Functionalised Silicone Polymers and Silicone-Coated Magnetic Nanoparticles. Masters thesis, National University of Ireland Maynooth.

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    Abstract

    Two families of amine-functionalised silicone polymers were prepared using monomeric (3-aminopropyl)triethoxysilane (APTES) and (3-trimethoxysilylpropyl)diethylene triamine (TMSPDT). Schiff base derivatives of these polymers were synthesised using salicylaldehyde. The same suite of polymers were also formed as a surface coating on magnetite nanoparticles (Fe3O4-MNPs). Copper(II) ions were coordinated to the pendant amine groups of all of the polymers. In vitro tests using the fungal pathogen, Candida albicans, revealed that the silicone polymers, their Cu(II) complexes and the Schiff base salicylate derivatives inhibited cell growth. None of the silicone-coated Fe3O4-MNPs were bioactive.

    Item Type: Thesis (Masters)
    Additional Information: M.Sc.
    Keywords: Synthesis; Characterisation; Antifungal Activity; Copper(II)-Functionalised Silicone Polymers; Silicone-Coated Magnetic Nanoparticles;
    Academic Unit: Faculty of Science and Engineering > Chemistry
    Item ID: 7531
    Depositing User: IR eTheses
    Date Deposited: 19 Oct 2016 10:41
    URI:

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