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    Designing sensitive and selective polymer/enzyme composite biosensors for brain monitoring in vivo


    O'Neill, Robert D. and Rocchitta, Gaia and McMahon, Colm P. and Serra, Pier A. and Lowry, John P. (2008) Designing sensitive and selective polymer/enzyme composite biosensors for brain monitoring in vivo. TrAC Trends in Analytical Chemistry, 27 (1). pp. 78-88. ISSN 0165-9936

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    Abstract

    Amperometric polymer/enzyme composite (PEC) biosensors, incorporating a poly(o-phenylenediamine) ultra-thin permselective barrier, possess a variety of characteristics that make them suitable for monitoring brain energy and neurotransmitter dynamics in vivo. This review highlights PEC sensitivity and selectivity parameters, which allow development of the basic design in a systematic way in order to improve their performance and to diversify the analyte range of these novel probes of brain function.

    Item Type: Article
    Keywords: Ascorbic acid interference; Brain monitoring; Electropolymerization; Glucose; Glutamate; H2O2 permeability; Polymer-modified electrode;
    Academic Unit: Faculty of Science and Engineering > Chemistry
    Item ID: 8034
    Identification Number: https://doi.org/10.1016/j.trac.2007.11.008
    Depositing User: John Lowry
    Date Deposited: 21 Mar 2017 16:20
    Journal or Publication Title: TrAC Trends in Analytical Chemistry
    Publisher: Elsevier
    Refereed: Yes
    Funders: Science Foundation Ireland (SFI), Health Research Board (HRB)
    URI:

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