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    The physics of protein self-assembly


    McManus, Jennifer J. and Charbonneau, Patrick and Zaccarelli, Emanuela and Asherie, Neer (2017) The physics of protein self-assembly. Current Opinion in Colloid and Interface Science, 22. pp. 73-79. ISSN 1359-0294

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    Abstract

    Understanding protein self-assembly is important formany biological and industrial processes. Proteins can selfassemble into crystals, filaments, gels, and other amorphous aggregates. The final forms include virus capsids and condensed phases associated with diseases such as amyloid fibrils. Although seemingly different, these assemblies all originate from fundamental protein interactions and are driven by similar thermodynamic and kinetic factors. Herewe reviewrecent advances in understanding protein self-assembly through a soft condensed matter perspective with an emphasis on three specific systems: globular proteins, viruses, and amyloid fibrils. We conclude with a discussion of unanswered questions in the field.

    Item Type: Article
    Keywords: Protein; Soft matter; Self-assembly; Crystallization; Amyloids; Virus capsids; Patchy colloids;
    Academic Unit: Faculty of Science and Engineering > Chemistry
    Item ID: 9243
    Identification Number: https://doi.org/10.1016/j.cocis.2016.02.011
    Depositing User: Jennifer McManus
    Date Deposited: 12 Feb 2018 17:20
    Journal or Publication Title: Current Opinion in Colloid and Interface Science
    Publisher: Elsevier
    Refereed: Yes
    URI:

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