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    In vitro cancer chemotherapeutic activity of 1,10-phenanthroline (phen), [Ag2(phen)3(mal)] Æ 2H2O, [Cu(phen)2(mal)] Æ 2H2O and [Mn(phen)2(mal)] Æ 2H2O (malH2 = malonic acid) using human cancer cells.


    Deegan, Carol and McCann, Malachy and Devereux, Michael and Coyle, Barry and Egan, Denise A. (2007) In vitro cancer chemotherapeutic activity of 1,10-phenanthroline (phen), [Ag2(phen)3(mal)] Æ 2H2O, [Cu(phen)2(mal)] Æ 2H2O and [Mn(phen)2(mal)] Æ 2H2O (malH2 = malonic acid) using human cancer cells. Cancer Letters, 247. pp. 224-233.

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    Abstract

    The chemotherapeutic potential of 1,10-phenanthroline (phen), and three of its transition metal complexes, namely [Cu(phen)2(mal)] Æ 2H2O, [Mn(phen)2(mal)] Æ 2H2O and [Ag2(phen)3(mal)] Æ 2H2O (malH2 = malonic acid) was determined using two human carcinoma cell lines (A-498 and Hep-G2). Phen and the three metal–phen complexes induced a concentration- dependent cytotoxic effect, with metal complexes demonstrating the greatest cytotoxic response. In comparative studies, IC50 values show cytotoxicity of between 3 and 18 times greater than that observed for the metal-based anti-cancer agent, cisplatin. All of the phen-based complexes inhibited DNA synthesis which did not appear to be mediated through intercalation. Also, the potential cancer chemotherapeutic application of these compounds was seen to be enhanced by results obtained from Ames tests, which showed all of the test agents and their phase I metabolites were non-mutagenic. Taken together, these results suggest that phen and the three metal–phen complexes may have a therapeutic role to play in the successful treatment and management of cancer.

    Item Type: Article
    Keywords: 1,10-Phenanthroline; Metal complexes; Cell carcinoma; DNA inhibition; Chemotherapeutic potential;
    Academic Unit: Faculty of Science and Engineering > Chemistry
    Item ID: 9715
    Depositing User: Dr. Malachy McCann
    Date Deposited: 26 Jul 2018 13:20
    Journal or Publication Title: Cancer Letters
    Refereed: Yes
    URI:

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