Asadpoordezaki, Ziba and Coogan, Andrew and Henley, Beverley
(2022)
Chronobiology of Parkinson's disease: Past, present and future.
European Journal of Neuroscience.
ISSN 0953-816X
Abstract
Parkinson’s disease is a neurodegenerative disorder predominately affecting
midbrain dopaminergic neurons that results in a broad range of motor and
non-motor symptoms. Sleep complaints are among the most common non-
motor symptoms, even in the prodromal period. Sleep alterations in Parkin-
son’s disease patients may be associated with dysregulation of circadian
rhythms, intrinsic 24-h cycles that control essential physiological functions, or
with side effects from levodopa medication and physical and mental health
challenges. The impact of circadian dysregulation on sleep disturbances in
Parkinson’s disease is not fully understood; as such, we review the systems,
cellular and molecular mechanisms that may underlie circadian perturbations
in Parkinson’s disease. We also discuss the potential benefits of chronobiology-
based personalized medicine in the management of Parkinson’s disease both
in terms of behavioural and pharmacological interventions. We propose that a
fuller understanding of circadian clock function may shed important new light
on the aetiology and symptomatology of the disease and may allow for
improvements in the quality of life for the millions of people with Parkinson’s
disease.
| Item Type: |
Article
|
| Keywords: |
chronotherapy; circadian clocks; circadian rhythm; neurodegenerative diseases; Parkinson’s
disease; sleep–wake disorders; |
| Academic Unit: |
Faculty of Science and Engineering > Psychology |
| Item ID: |
16797 |
| Identification Number: |
https://doi.org/10.1111/ejn.15859 |
| Depositing User: |
Beverley Henley
|
| Date Deposited: |
05 Jan 2023 12:10 |
| Journal or Publication Title: |
European Journal of Neuroscience |
| Publisher: |
Blackwell Publishing Ltd |
| Refereed: |
No |
| URI: |
|
| Use Licence: |
This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available
here |
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