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    Applications of Raman spectroscopy to the urinary bladder for cancer diagnostics


    Kerr, Laura and Domijan, Katarina and Cullen, Ivor and Hennelly, Bryan M. (2014) Applications of Raman spectroscopy to the urinary bladder for cancer diagnostics. Photonics and Lasers in Medicine, 3 (3). pp. 193-224. ISSN 2193-0643

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    Abstract

    Biomolecular changes associated with cancer progression can be identified using Raman spectroscopy, allowing for this technique to be utilized as a non-invasive tool for the diagnosis of bladder cancer. Applications of Raman spectroscopy for diagnostics in real-time have consistently produced higher sensitivities and specificities than current clinical methods. This technique can be applied in vivo during bladder visualization (cystoscopic) procedures as an “optical biopsy” or in vitro to cells obtained from urine cytology specimens. This review follows the evolution of studies in this field from the first in vitro experiment to the most recent in vivo application, identifies how diagnostic algorithms are developed, and provides molecular information associated with the etiology of the biochemical continuum of disease progression. Future prospects for the application of Raman spectroscopy in bladder cancer diagnostics are also discussed.

    Item Type: Article
    Additional Information: Cite as: Kerr, L., Domijan, K., Cullen, I., et al. (2014). Applications of Raman spectroscopy to the urinary bladder for cancer diagnostics. Photonics & Lasers in Medicine, 3(3), pp. 193-224.
    Keywords: Raman microspectroscopy; bladder; cancer diagnostics; Raman fiber-optic probe;
    Academic Unit: Faculty of Science and Engineering > Computer Science
    Faculty of Science and Engineering > Electronic Engineering
    Faculty of Science and Engineering > Mathematics and Statistics
    Faculty of Science and Engineering > Research Institutes > Hamilton Institute
    Item ID: 10014
    Identification Number: https://doi.org/10.1515/plm-2014-0004
    Depositing User: Katarina Domijan
    Date Deposited: 27 Sep 2018 13:53
    Journal or Publication Title: Photonics and Lasers in Medicine
    Publisher: de Gruyter
    Refereed: Yes
    URI:

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