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    Intracellular competition for fates in the immune system

    Duffy, Ken R. and Hodgkin, Philip D. (2012) Intracellular competition for fates in the immune system. Trends in Cell Biology, 22 (9). pp. 457-464. ISSN 0962-8924

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    During an adaptive immune response, lymphocytes proliferate for five to 20 generations, differentiating to take on effector functions, before cessation and cell death become dominant. Recent experimental methodologies enable direct observation of individual lymphocytes and the times at which they adopt fates. Data from these experiments reveal diversity in fate selection, heterogeneity and involved correlation structures in times to fate, as well as considerable familial correlations. Despite the significant complexity, these data are consistent with the simple hypothesis that each cell possesses autonomous processes, subject to temporal competition, leading to each fate. This article addresses the evidence for this hypothesis, its hallmarks, and, should it be an appropriate description of a cell system, its ramifications for manipulation.

    Item Type: Article
    Keywords: adaptive immune response; stochastic fate determination; autonomous competition hypothesis;
    Academic Unit: Faculty of Science and Engineering > Research Institutes > Hamilton Institute
    Item ID: 10170
    Identification Number:
    Depositing User: Dr Ken Duffy
    Date Deposited: 02 Nov 2018 16:40
    Journal or Publication Title: Trends in Cell Biology
    Publisher: Elsevier
    Refereed: Yes

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