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    The influence of macrophages on mesenchymal stromal cell therapy: passive or aggressive agents?


    Carty, Fiona and Mahon, Bernard P. and English, Karen (2017) The influence of macrophages on mesenchymal stromal cell therapy: passive or aggressive agents? Clinical and Experimental Immunology, 188. pp. 1-11. ISSN 1365-2249

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    Abstract

    Mesenchymal stromal cells (MSC) have emerged as promising cell therapies for multiple conditions based on demonstrations of their potent immunomodulatory and regenerative capacities in models of inflammatory disease. Understanding the effects of MSC on T cells has dominated the majority of work carried out in this field to date; recently, however, a number of studies have shown that the therapeutic effect of MSC requires the presence of macrophages. It is timely to review the mechanisms and manner by which MSC modulate macrophage populations in order to design more effective MSC therapies and clinical studies. A complex crosstalk exists through which MSC and macrophages communicate, a communication that is not controlled exclusively by MSC. Here, we examine the evidence that suggests that MSC not only respond to inflammatory macrophages and adjust their secretome accordingly, but also that macrophages respond to encounters with MSC, creating a feedback loop which contributes to the immune regulation observed following MSC therapy. Future studies examining the effects of MSC on macrophages should consider the antagonistic role that macrophages play in this exchange.

    Item Type: Article
    Keywords: inflammation; macrophage; mesenchymal stem cells;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 10577
    Identification Number: https://doi.org/10.1111/cei.12929
    Depositing User: Karen English
    Date Deposited: 25 Feb 2019 11:39
    Journal or Publication Title: Clinical and Experimental Immunology
    Publisher: Wiley
    Refereed: Yes
    URI:

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