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    Mesenchymal Stromal Cells in Transplantation Rejection and Tolerance


    English, Karen and Wood, Kathryn J. (2013) Mesenchymal Stromal Cells in Transplantation Rejection and Tolerance. Cold Spring Harbor perspectives in medicine, 3. ISSN 2157-1422

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    Abstract

    Mesenchymal stromal cells (MSCs) have recently emerged as promising candidates for cell-based immunotherapy in solid organ transplantation (SOT). In addition to immune modu-lation, MSCs possessproreparative propertiesand preclinical studies indicatethat MSCs havethe capacity to prolong graft survival and in some cases induce tolerance. Currently, theapplication of MSCs in SOT is being evaluated in phase I/II clinical trials. Whereas themechanisms of action used by MSC immunomodulation have been somewhat elucidatedin vitro, the data from preclinical transplant models have been unclear. Furthermore, theoptimal timing, dose,and routeof administration remain tobe elucidated.Importantly, MSCshave the ability to sense their environment, which may influence their function. In thisarticle, we discuss the impact of the local microenvironment on MSCs and the mechanismsof MSC immunomodulation in the setting of SOT.

    Item Type: Article
    Keywords: Mesenchymal Stromal Cells; Transplantation Rejection; Tolerance;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 10583
    Identification Number: https://doi.org/10.1101/cshperspect.a015560
    Depositing User: Karen English
    Date Deposited: 25 Feb 2019 14:40
    Journal or Publication Title: Cold Spring Harbor perspectives in medicine
    Refereed: Yes
    URI:

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