MURAL - Maynooth University Research Archive Library



    Antibiotic resistance in European wastewater treatment plants mirrors the pattern of clinical antibiotic resistance prevalence


    Pärnänen, Katariina M. M. and Narciso-da-Rocha, Carlos and Kneis, David and Berendonk, Thomas U. and Cacace, Damlano and Do, Thi Thuy and Elpers, Christian and Fatta-Kassinos, Despo and Henriques, Isabel and Jaeger, Thomas and Karkman, Antti and Martinez, Jose Luis and Michael, Stella G. and Michael-Kordatou, Irene and O’Sullivan, Kristin and Rodriguez-Mozaz, Sara and Schwartz, Thomas and Sheng, Hongjie and Sørum, Henning and Stedtfeld, Robert D. and Tiedje, James M. and Varela Della Giustina, Saulo and Walsh, Fiona and Vaz-Moreira, Ivone and Virta, Marko and Manaia, Célia M. (2019) Antibiotic resistance in European wastewater treatment plants mirrors the pattern of clinical antibiotic resistance prevalence. Science Advances, 5 (3). ISSN 2375-2548

    [img]
    Preview
    Download (1MB) | Preview


    Share your research

    Twitter Facebook LinkedIn GooglePlus Email more...



    Add this article to your Mendeley library


    Abstract

    Integrated antibiotic resistance (AR) surveillance is one of the objectives of the World Health Organization global action plan on antimicrobial resistance. Urban wastewater treatment plants (UWTPs) are among the most import- ant receptors and sources of environmental AR. On the basis of the consistent observation of an increasing north- to-south clinical AR prevalence in Europe, this study compared the influent and final effluent of 12 UWTPs located in seven countries (Portugal, Spain, Ireland, Cyprus, Germany, Finland, and Norway). Using highly parallel quanti - tative polymerase chain reaction, we analyzed 229 resistance genes and 25 mobile genetic elements. This first trans-Europe surveillance showed that UWTP AR profiles mirror the AR gradient observed in clinics. Antibiotic use, environmental temperature, and UWTP size were important factors related with resistance persistence and spread in the environment. These results highlight the need to implement regular surveillance and control mea- sures, which may need to be appropriate for the geographic regions.

    Item Type: Article
    Keywords: Antibiotic resistance; European wastewater treatment plants; pattern; clinical antibiotic resistance;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 10660
    Identification Number: https://doi.org/10.1126/sciadv.aau9124
    Depositing User: Fiona Walsh
    Date Deposited: 29 Mar 2019 12:37
    Journal or Publication Title: Science Advances
    Publisher: American Association for the Advancement of Science
    Refereed: Yes
    URI:

    Repository Staff Only(login required)

    View Item Item control page

    Downloads

    Downloads per month over past year