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    How does healthy aging impact on the circadian clock?


    Popa-Wagner, Aurel and Buga, Ana-Maria and Dumitrascu, Dinu Iuliu and Uzoni, Adriana and Thome, Johannes and Coogan, Andrew (2015) How does healthy aging impact on the circadian clock? Journal of Neural Transmission, 124 (Supp.1). pp. 89-97. ISSN 0300-9564

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    Abstract

    Circadian rhythms are recurring patterns in a host of physiological and other parameters that recur with periods of near 24 h. These rhythms reflect the temporal organization of an organism’s homeostatic control systems and as such are key processes in ensuring optimal physiological performance. Dysfunction of circadian processes is linked with adverse health conditions. In this review we highlight the evidence that normal, healthy aging is associated with changes in the circadian system; we examine the molecular mechanisms through which such changes may arise, discuss whether more robust circadian function is a predictor of longevity and highlight the role of circadian rhythms in age-related diseases. Overall, the literature shows that aging is associated with marked changes in circadian processes, both at the behavioral and molecular levels, and the molecular mechanisms through which such changes arise remain to be elucidated, but may involve inflammatory process, redox homeostasis and epigenetic modifications. Understanding the nature of age-related circadian dysfunction will allow for the design of chronotherapeutic intervention strategies to attenuate circadian dysfunction and thus improve health and quality of life.

    Item Type: Article
    Additional Information: Cite as: Popa-Wagner, A., Buga, AM., Dumitrascu, D.I. et al. J Neural Transm (2017) 124(Suppl 1): 89. https://doi.org/10.1007/s00702-015-1424-2
    Keywords: Circadian; Aging; Clock gene; Inflammation; Longevity;
    Academic Unit: Faculty of Science and Engineering > Psychology
    Item ID: 10732
    Identification Number: https://doi.org/10.1007/s00702-015-1424-2
    Depositing User: Dr. Andrew Coogan
    Date Deposited: 16 Apr 2019 14:54
    Journal or Publication Title: Journal of Neural Transmission
    Publisher: Springer Verlag
    Refereed: Yes
    URI:

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