MURAL - Maynooth University Research Archive Library



    Neutrophil-derived microRNAs put the (DNA) breaks on intestinal mucosal healing


    McNamee, Eóin (2019) Neutrophil-derived microRNAs put the (DNA) breaks on intestinal mucosal healing. Journal of Clinical Investigation, 129 (2). pp. 499-502. ISSN 1558-8238

    [img]
    Preview
    Download (1MB) | Preview


    Share your research

    Twitter Facebook LinkedIn GooglePlus Email more...



    Add this article to your Mendeley library


    Abstract

    A predominant feature of intestinal inflammation is the accumulation of neutrophils, which dictates a fine balance between epithelial repair or progression to chronic inflammation. While the processes of mucosal healing are well studied, how neutrophils advance an inflammatory insult towards epithelial neoplasia is less understood. In this issue of the JCI, Butin-Israeli et al. outline a mechanism whereby neutrophils control epithelial fitness and genomic instability via delivery of miR-23a–and miR-155–containing microparticles. Localized delivery of antisense oligonucleotides targeting miR-23a and miR-155 reversed this genomic instability and accelerated mucosal healing. This mechanism of neutrophil-derived microRNA shuttling opens up new therapeutic potential to enhance epithelial healing and limit mucosal injury.

    Item Type: Article
    Keywords: Neutrophil-derived microRNAs; intestinal mucosal healing; intestinal inflammation;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 10934
    Identification Number: https://doi.org/10.1172/JCI125779
    Depositing User: Eoin McNamee
    Date Deposited: 11 Jul 2019 14:19
    Journal or Publication Title: Journal of Clinical Investigation
    Publisher: American Society for Clinical Investigation
    Refereed: Yes
    URI:

      Repository Staff Only(login required)

      View Item Item control page

      Downloads

      Downloads per month over past year