Jones, Jennifer C. and Brindley, Constance D. and Elder, Nicholas H. and Myers, Martin G. and Rajala, Michael W. and Dekaney, Christopher M. and McNamee, Eóin N. and Frey, Mark R. and Shroyer, Noah F. and Dempsey, Peter J. (2018) Cellular Plasticity of Defa4Cre-Expressing Paneth Cells in Response to Notch Activation and Intestinal Injury. Cellular and Molecular Gastroenterology and Hepatology, 7 (3). ISSN 2352-345X

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Abstract

Upon leucine-rich repeat-containing G-protein–coupled receptor 5–positive crypt base columnar loss, reserve stem cell populations can repopulate the stem cell niche. This study shows that defensin a4-Cre–expressing cells are fated to become mature Paneth cells during normal homeostasis, but Notch activation or doxorubicin injury causes their dedifferentiation into multipotent stem cells.

Item Type:	Article
Additional Information:	© 2019 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords:	Defensin; Paneth Cell; Intestinal Stem Cells; Regeneration; Enteroid; Notch; Chemotherapy;
Academic Unit:	Faculty of Science and Engineering > Biology
Item ID:	10935
Identification Number:	https://doi.org/10.1016/j.jcmgh.2018.11.004
Depositing User:	Eoin McNamee
Date Deposited:	11 Jul 2019 16:23
Journal or Publication Title:	Cellular and Molecular Gastroenterology and Hepatology
Publisher:	Elsevier
Refereed:	Yes
URI:	https://www.cmghjournal.org/
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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