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    Cellular Plasticity of Defa4Cre-Expressing Paneth Cells in Response to Notch Activation and Intestinal Injury


    Jones, Jennifer C. and Brindley, Constance D. and Elder, Nicholas H. and Myers, Martin G. and Rajala, Michael W. and Dekaney, Christopher M. and McNamee, Eóin and Frey, Mark R. and Shroyer, Noah F. and Dempsey, Peter J. (2018) Cellular Plasticity of Defa4Cre-Expressing Paneth Cells in Response to Notch Activation and Intestinal Injury. Cellular and Molecular Gastroenterology and Hepatology, 7 (3). ISSN 2352-345X

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    Abstract

    Upon leucine-rich repeat-containing G-protein–coupled receptor 5–positive crypt base columnar loss, reserve stem cell populations can repopulate the stem cell niche. This study shows that defensin a4-Cre–expressing cells are fated to become mature Paneth cells during normal homeostasis, but Notch activation or doxorubicin injury causes their dedifferentiation into multipotent stem cells.

    Item Type: Article
    Additional Information: © 2019 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
    Keywords: Defensin; Paneth Cell; Intestinal Stem Cells; Regeneration; Enteroid; Notch; Chemotherapy;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 10935
    Identification Number: https://doi.org/10.1016/j.jcmgh.2018.11.004
    Depositing User: Eoin McNamee
    Date Deposited: 11 Jul 2019 16:23
    Journal or Publication Title: Cellular and Molecular Gastroenterology and Hepatology
    Publisher: Elsevier
    Refereed: Yes
    URI:

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