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    MybA, a new player driving survival of the conidium of the human pathogen Aspergillus fumigatus


    Bayram, Ozlem Sarikaya and Latgé, Jean Paul and Bayram, Ozgur (2017) MybA, a new player driving survival of the conidium of the human pathogen Aspergillus fumigatus. Current Genetics, 64 (1). pp. 141-146. ISSN 1432-0983

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    Abstract

    Aspergillus fumigatus is an opportunistic human pathogen that causes various complications in patients with a weakened immune system functions. Asexual spores of A. fumigatus are responsible for initiation of aspergillosis. Long-term viability and proper germination of dormant conidia depend on trehalose accumulation, which protect the spores against thermal and oxidative stress. A putative Myb transcription factor, MybA has been recently found to be responsible for a variety of physiological and molecular roles ranging from conidiation, spore viability, trehalose accumulation, cell wall integrity and protection against reactive oxygen species. In this perspective review, we discuss the recent findings of MybA and its overlapping functions with the other regulators of conidia viability and trehalose accumulation. Therefore, the aim of this perspective is to raise interesting and stimulating questions on the molecular functions of MybA in conidiation and trehalose biogenesis and to question its genetic and physical interactions with the other regulators of conidial viability. Keywords

    Item Type: Article
    Additional Information: Cite as: Sarikaya Bayram, Ö., Latgé, J.P. & Bayram, Ö. Curr Genet (2018) 64: 141. https://doi.org/10.1007/s00294-017-0740-5
    Keywords: MybA; Spore viability; VelB-VosA; Cell wall; Aspergillus fumigatus · AtfA; WetA;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 11000
    Identification Number: https://doi.org/10.1007/s00294-017-0740-5
    Depositing User: Ozgur Bayram
    Date Deposited: 29 Aug 2019 14:26
    Journal or Publication Title: Current Genetics
    Publisher: Springer
    Refereed: Yes
    Funders: Science Foundation Ireland (SFI), Irish Research Council (IRC)
    URI:

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