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    Molecular and physiological roles of Pellino E3 ubiquitin ligases in immunity


    Humphries, Fiachra and Moynagh, Paul N. (2015) Molecular and physiological roles of Pellino E3 ubiquitin ligases in immunity. Immunological Reviews, 266 (1). pp. 93-108. ISSN 1600-065X

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    Abstract

    The sensing of foreign agents by the innate and adaptive immune system triggers complex signal transduction cascades that culminate in expression of gene patterns that facilitate host protection from the invading agent. Post‐translational modification of intracellular signaling proteins in these pathways is a key regulatory mechanism with ubiquitination being one of the important processes that controls levels and activities of signaling molecules. E3 ubiquitin ligases are the determining enzymes in dictating the ubiquitination status of individual proteins. Among these hundred E3 ubiquitin ligases are a family of Pellino proteins that are emerging to be important players in immunity and beyond. Herein, we review the roles of the Pellino E3 ubiquitin ligases in innate and adaptive immunity. We discuss their early discovery and characterization and how this has been aided by the highly conserved nature of innate immune signaling across evolution. We describe the molecular roles of Pellino proteins in immune signaling with particular emphasis on their involvement in pathogen recognition receptor (PRR) signaling. The growing appreciation of the importance of Pellino proteins in a wide range of immune‐mediated diseases are also evaluated.

    Item Type: Article
    Keywords: Pellino E3 ubiquitin ligases; innate immunity; Toll-like receptors; NODlike receptors; inflammation; ubiquitination;
    Academic Unit: Faculty of Science and Engineering > Biology
    Faculty of Science and Engineering > Research Institutes > Institute of Immunology
    Item ID: 11042
    Identification Number: https://doi.org/10.1111/imr.12306
    Depositing User: Professor Paul Moynagh
    Date Deposited: 16 Sep 2019 14:22
    Journal or Publication Title: Immunological Reviews
    Publisher: Wiley
    Refereed: Yes
    Funders: Science Foundation Ireland (SFI)
    URI:

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